alexa [High performance liquid chromatographic assay for aceclofenac in plasma and its pharmacokinetics in dogs].
Pharmaceutical Sciences

Pharmaceutical Sciences

Pharmaceutica Analytica Acta

Author(s): Liu XQ, Chen XJ, Zhao LH, Peng JH

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Abstract A sensitive and simplified high performance liquid chromatographic procedure has been developed for the quantification of aceclofenac and its major metabolite in dog plasma. The recovery of aceclofenac was 91.3\%-96.9\%. The relative standard deviation was 3.69\%-8.13\%. The calibration curve was linear in the range from 0.050 to 51.2 with gamma = 0.9998. The detection limit of the method is 10 for aceclofenac. Plasma concentrations of both aceclofenac and its major metabolite were simultaneously determined. After oral medication of aceclofenac to dogs at the dose of 2.5, the drug was absorbed rapidly and reached its peak level in plasma at about 12 min. The plasma drug concentration-time course conformed to a 2-compartment open model with a first order absorption. The mean value of T1/2 alpha and T1/2 beta for aceclofenac were 2.5 min and 137 min respectively. Plasma diclofenac concentration, a major metabolite of aceclofenac, reached its maximum at about 110 min, the mean Cmax for diclofenac was 3.2 The mean terminal elimination half-life for diclofenac was 140 min.
This article was published in Yao Xue Xue Bao and referenced in Pharmaceutica Analytica Acta

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