Author(s): Velayati AA, Farnia P, Mozafari M, Sheikholeslami MF, Karahrudi MA,
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Abstract We determined the prevalence of rifampin-monoresistant tuberculosis (RMR-TB) in Iran. Because development of RMR-TB is not common, we also identified the major risk factors associated with RMR-TB reported from different provinces of Iran. Data for 3,020 TB patients who remained or became smear positive after two, four, six, and nine months of standard first-line chemotherapy were retrospectively analyzed. Of 3,020 patients, 1,242 patients (41.1\%) were culture and DNA positive for Mycobacterium tuberculosis. Of these patients, 73 (7.4\%) patients had monoresistant isolates to rifampin, which was significantly higher than that for multidrug-resistant TB (5.8\%). The average rate of RMR-TB in the studied population ranged from 5\% to 10\%. Classical investigation showed that 33.6\% of patients had either a previous or family history of TB. Molecular epidemiology methods (i.e., spoligotyping and Mycobacterium interspersed repetitive unit-variable number tandem repeat), defined transmission link in three clusters (13\%). These results outline the urgent need for a comprehensive plan for detection and treatment of RMR-TB cases.
This article was published in Am J Trop Med Hyg
and referenced in Mycobacterial Diseases