alexa High rate of spontaneous negativity for hepatitis C virus RNA after establishment of chronic infection in Alaska Natives.
Pharmaceutical Sciences

Pharmaceutical Sciences

Journal of Bioequivalence & Bioavailability

Author(s): Scott JD, McMahon BJ, Bruden D, Sullivan D, Homan C,

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Abstract BACKGROUND: Hepatitis C virus (HCV) leads to chronic infection in 70\%-85\% of exposed patients. Spontaneous clearance of the virus after chronic infection is believed to occur rarely. METHODS: Alaska Natives who tested positive for HCV antibodies were enrolled in a prospective study that began in 1994 and were followed up on a regular basis. Individuals who tested positive for HCV RNA on 3 separate dates, each of which were at least 1 year apart, were included. Being negative for the virus was defined as having at least 1 negative HCV RNA test result after chronic viremia had been established. RESULTS: Of the 815 patients enrolled in the cohort, 139 met entry criteria and were observed for a mean period of 7.0 years. Eleven (8\%) of the persons had at least 1 test in which HCV RNA was undetectable; 7 were classified as having either possible or probable clearance of the virus, corresponding to an annualized clearance rate of 0.74\% per person-year (95\% CI, 0.30\%-1.53\%). Of 9 patients who underwent subsequent HCV RNA testing, 5 (56\%) had negative test results. A low HCV RNA level was significantly associated with spontaneous nondetectability of HCV RNA. CONCLUSION: Spontaneous HCV RNA negativity during chronic HCV infection is a surprisingly frequent event and is associated with low HCV RNA titers. Knowledge of immunologic determinants of clearance may open up avenues of novel therapy. This article was published in Clin Infect Dis and referenced in Journal of Bioequivalence & Bioavailability

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