alexa High rates of regional failure in squamous cell carcinoma of the hard palate and maxillary alveolus.


Journal of Medical Diagnostic Methods

Author(s): Morris LG, Patel SG, Shah JP, Ganly I

Abstract Share this page

Abstract BACKGROUND: The purpose of this study was to determine the incidence of neck metastasis in hard palate and maxillary alveolus squamous cell carcinoma (SCC) and to identify factors predictive of regional failure. METHODS: In 139 patients treated for SCC of the hard palate and maxillary alveolus (from 1985-2006), the incidence rates of regional metastasis at presentation and at recurrence were calculated. Factors predictive of regional recurrence-free survival were identified on Cox multivariable regression analysis. RESULTS: Regional failure occurred in 28.4\% of patients and was significantly associated with pathologic T classification, ranging from 18.7\% (pT1) to 37.3\% (pT4). T classification was an independent predictor of regional recurrence-free survival (RRFS) on multivariable analysis. Most patients (65.6\%) with regional recurrence were not able to be salvaged. CONCLUSION: Patients with T2 to T4 primary tumors of the hard palate and maxillary alveolus exhibited high rates of regional failure. In most cases, successful salvage was not achieved. Elective treatment of the neck with surgery or radiation is therefore recommended. Copyright © 2010 Wiley Periodicals, Inc.
This article was published in Head Neck and referenced in Journal of Medical Diagnostic Methods

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version