alexa High-dose vitamin C management in dapsone-induced methemoglobinemia.
Toxicology

Toxicology

Journal of Clinical Toxicology

Author(s): Park SY, Lee KW, Kang TS, Park SY, Lee KW, Kang TS, Park SY, Lee KW, Kang TS, Park SY, Lee KW, Kang TS

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Abstract Methylene blue is the first-choice treatment of methemoglobinemia, but it is not readily available in most Korean emergency departments because of an import suspension. An 84-year-old woman with dapsone-induced massive methemoglobinemia visited our emergency department for unclear mentality and cyanosis. Because methylene blue was not available, we intravenously administrated vitamin C (VC) for symptomatic methemoglobinemia, although VC is not a universally accepted treatment. Vitamin C (10 g intravenously) administered 6 hourly successfully treated the dapsone-induced methemoglobinemia and did not adversely affect renal functions. Thus,we recommend that if methylene blue is unavailable, 6 hourly intravenous administrations of 10 g of VC should be considered for dapsone-induced methemoglobinemia. This article was published in Am J Emerg Med and referenced in Journal of Clinical Toxicology

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