alexa Higher risk of microvascular complications in smokers with type 1 diabetes despite intensive insulin therapy.
Immunology

Immunology

Immunome Research

Author(s): Uruska A, Araszkiewicz A, Uruski P, ZozulinskaZiolkiewicz D, Uruska A, Araszkiewicz A, Uruski P, ZozulinskaZiolkiewicz D

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Abstract AIM: The aim of the study was to evaluate the relationship between smoking status and the incidence of microvascular complications in patients with type 1 diabetes (DM1), treated with intensive functional insulin therapy (IFIT) from the onset of the disease. METHODS: 81 participants (51 men, 30 women) of Poznan Prospective Study (PoProStu) with mean age of 34.0 ± 6.4 years were included in this analysis. Patients were observed for 10.0 ± 1.5 years. Evaluation of microvascular complications of diabetes, such as retinopathy, diabetic kidney disease and neuropathy was performed. Patients were divided into two groups depending on the smoking status: smokers and non-smokers. RESULTS: In the group of smokers (n=36) in comparison with patients who had never smoked (n=45) any microangiopathy (58.3\% vs 33.3\%, p=0.02), retinopathy (44.4\% vs 20\%, p=0.02), diabetic kidney disease (47.2\% vs 24.4\%, p=0.03) and neuropathy (25\% vs 4.4\%, p=0.02) were found more often. A significant relationship, adjusted for age, sex, duration of diabetes, presence of hypertension and HbA1c between smoking and neuropathy and retinopathy was revealed [OR 10.16 (95\%CI 1.59-64.95); p=0.01 and OR 3.50 (95\%CI 1.01-12.12); p=0.04, respectively]. CONCLUSION: The results show that in patients with DM1, there is a strong relationship between smoking and the diabetic microvascular complications, especially with neuropathy, despite treatment from the initial diagnosis with intensive insulin therapy. Copyright © 2014 Elsevier Inc. All rights reserved. This article was published in Microvasc Res and referenced in Immunome Research

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