alexa Hippocampal neuronal loss and regional hypometabolism in temporal lobe epilepsy.


International Journal of Neurorehabilitation

Author(s): Henry TR, Babb TL, Engel J Jr, Mazziotta JC, Phelps ME,

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Abstract The pathophysiology of widespread interictal hypometabolism in temporal lobe epilepsy is unknown but might reflect neuronal loss and diaschisis. We found no significant correlation between any cortical region's metabolism on preoperative [18F]fluorodeoxyglucose positron emission tomography and neuronal density of resected hippocampi in 40 patients. We conclude that hippocampal neuronal loss and diaschisis cannot account for the regional interictal hypometabolism of temporal lobe epilepsy. This article was published in Ann Neurol and referenced in International Journal of Neurorehabilitation

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