alexa Histopathological Growth Pattern, Proteolysis and Angiogenesis in Chemonaive Patients Resected for Multiple Colorectal Liver Metastases
Oncology

Oncology

Journal of Lung Cancer Diagnosis & Treatment

Author(s): Rikke Lvendahl Eefsen, Gert G Van den Eynden, Gunilla HyerHansen, Pnina Brodt, Andr Wettergren

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The purpose of this study was to characterise growth patterns, proteolysis, and angiogenesis in colorectal liver metastases from chemonaive patients with multiple liver metastases. Twenty-four patients were included in the study, resected for a median of 2.6 metastases. The growth pattern distribution was 25.8% desmoplastic, 33.9% pushing, and 21% replacement. In 20 patients, identical growth patterns were detected in all metastases, but in 8 of these patients, a second growth pattern was also present in one or two of the metastases. In the remaining 4 patients, no general growth pattern was observed, although none of the liver metastases included more than two growth patterns. Overall, a mixed growth pattern was demonstrated in 19.3% of the liver metastases. Compared to metastases with pushing, those with desmoplastic growth pattern had a significantly up-regulated expression of urokinase-type plasminogen activator receptor ( 𝑃 = 0 . 0 0 0 8 ). Angiogenesis was most pronounced in metastases with a pushing growth pattern in comparison to those with desmoplastic ( 𝑃 = 0 . 0 0 0 7 ) and replacement growth pattern ( 𝑃 = 0 . 0 2 1 ). Although a minor fraction of the patients harboured metastases with different growth patterns, we observed a tendency toward growth pattern uniformity in the liver metastases arising in the same patient. The result suggests that the growth pattern of liver metastases is not a random phenomenon.

This article was published in Journal of Oncology and referenced in Journal of Lung Cancer Diagnosis & Treatment

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