Author(s): Chany AC, Tresse C, Casarotto V, Blanchard N, Chany AC, Tresse C, Casarotto V, Blanchard N
Abstract Share this page
Abstract Mycobacterium ulcerans infections (Buruli ulcer disease) have a long history that can be traced back 150 years. The successive discoveries of the mycobacteria in 1948 and of mycolactone A/B in 1999, the toxin responsible for this dramatic necrotic skin disease, resulted in a paradigm shift concerning the disease itself and in a broader sense, delineated an entirely new role for bioactive polyketides as virulence factors. The fascinating history, biology and chemistry of M. ulcerans infections are discussed in this review.
This article was published in Nat Prod Rep
and referenced in Journal of Infectious Diseases & Preventive Medicine