alexa History of Fixed-Dose Combination Therapy for Hypertension
Pharmaceutical Sciences

Pharmaceutical Sciences

Journal of Bioequivalence & Bioavailability

Author(s): Wofford JL

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The excellent historical perspective on fixed-dose combination therapies for hypertension by Epstein and Bakris did not include discussion of the earliest combination medications for hypertension. Their article misstated that fixed-dose combinations have always included a diuretic as a component until the release of an angiotensin-converting enzyme inhibitor—calcium antagonist combination this year. A look even further back in history reveals the earlier existence of several nondiuretic combination medications that illustrate the very principles used to justify the resurging interest in combination antihypertensives.

This article was published in Arch Intern Med and referenced in Journal of Bioequivalence & Bioavailability

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