alexa HIV inhibitory natural products. 26. Quinoline alkaloids from Euodia roxburghiana.
Microbiology

Microbiology

Virology & Mycology

Author(s): McCormick JL, McKee TC, Cardellina JH nd, Boyd MR

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Abstract Bioassay-directed fractionation of the CH2Cl2-MeOH extract of Euodia roxburghiana resulted in the isolation of two known quinoline alkaloids, buchapine (1) and 2, and three new furoquinoline alkaloids, roxiamines A, B, and C (3-5). Compounds 1 and 2 protected CEM-SS cells from the cytopathic effects of HIV-1 in vitro (EC50 0.94 and 1.64 microM, respectively), but 3-5 were inactive against HIV-1. This article was published in J Nat Prod and referenced in Virology & Mycology

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