alexa HIV type 1 genetic diversity in newly diagnosed Cuban patients.
Infectious Diseases

Infectious Diseases

Journal of AIDS & Clinical Research

Author(s): Machado LY, Blanco M, Dubed M, Daz HM, Ruiz NM,

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Abstract Knowledge of the genetic diversity of HIV-1 constitutes a fundamental premise in the epidemiological surveillance. In the present study, the HIV-1 genetic variability from 142 Cuban patients who were diagnosed with HIV-1 infection during 2009 and 2010 was determined. HIV-1 subtypes were determined by partial RT-PCR and sequencing of the HIV-1 pol gene. The phylogenetic analysis showed that 47 (33.1 \%) samples were subtypes B and 95 (66.9 \%) were non-B subtypes, where G, H, and C subtypes, as well as the recombinant forms CRF19_cpx, CRF18_cpx, and CRFs BG, were included. The circulation of CRF05_DF was detected for the first time in Cuba. The analyses of recombinants showed the presence of recombinant CRF18_cpx/CRF19_cpx. The study confirms the high genetic diversity of HIV-1 and the circulation of new genetic variants in the studied population, which indicates the importance of maintaining constant epidemiological surveillance in Cuba. This article was published in AIDS Res Hum Retroviruses and referenced in Journal of AIDS & Clinical Research

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