Author(s): Ndiaye HD, Tchiakpe E, Vidal N, Ndiaye O, Diop AK,
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Abstract HIV-1 epidemics are expanding among men who have sex with men in low- and middle-income countries. To confirm and further explore preliminary data in Senegal, we aimed to determine 3 years after a first study the HIV-1 genetic diversity in three different viral regions. From 109 samples available in 2007, 93 were sequenced in gag, 77 in env, and 60 in pol. Phylogenetic analysis showed that subtype C predominated (38-52\%), followed by CRF02_AG (30-40\%), subtype B (13-17\%), and CRF09_cpx (2.6-5\%). Subsubtype A3 and strains tightly linked to CRF43_02G were identified in env and gag, respectively, and 12\% of the samples were unique recombinants. Six transmission chains involving two to seven individuals were identified. Some strains carried resistance mutations inside transmission chains. This study confirmed the existence of a dual epidemic in Senegal and emphasized the need to strengthen prevention programs to avoid strains intermixing between low-risk women and high-risk men.
This article was published in AIDS Res Hum Retroviruses
and referenced in Journal of Antivirals & Antiretrovirals