alexa HIV-1 transmitted drug resistance and genetic diversity among patients from Piauí State, Northeast Brazil.
Infectious Diseases

Infectious Diseases

Journal of AIDS & Clinical Research

Author(s): Moura ME, da Guarda Reis MN, Lima YA, Eullio KD, Cardoso LP,

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Abstract HIV-1 transmitted-drug-resistance and genetic diversity are dynamic and may differ in distinct locations/risk groups. In Brazil, increased AIDS incidence and related mortality have been detected in the Northeast region, differently from the epicenter in the Southeast. This cross-sectional study describes transmitted-dru- resistance and HIV-1 subtypes in protease/PR and reverse transcriptase/RT regions among antiretroviral na√Įve patients from Piau√≠ State, Northeast Brazil. Among 96 patients recruited 89 (92.7\%) had HIV-1 PR/RT regions sequenced: 44 females and 45 males, 22 self-declared as men who have sex with men. Transmitted-drug-resistance was investigated by CPR tool (Stanford HIV-1 Drug Resistance/SDRM). HIV-1 subtypes were assigned by REGA and phylogenetic inference. Overall, transmitted-drug-resistance rate was 11.2\% (10/89; CI 95\%: 5.8-19.1\%); 22.7\% among men who have sex with men (5/22; CI 95\%: 8.8-43.4\%), 10\% in heterosexual men (2/20; CI 95\%: 1.7-29.3\%) and 6.8\% in women (3/44; CI 95\%: 1.8-17.4\%). Singleton mutations to protease-inhibitor/PI, nucleoside-reverse-transcriptase-inhibitor/NRTI or non-nucleoside-reverse-transcriptase-inhibitor/NNRTI predominated (8/10): PI mutations (M46L, V82F, L90M); NRTI mutations (M41L, D67N) and NNRTI mutations (K103N/S). Dual class resistance mutations to NRTI and NNRTI were observed: T215L (NRTI), Y188L (NNRTI) and T215N (NRTI), F227L (NNRTI). Subtype B prevailed (86.6\%; 77/89), followed by subtype F1 (1.1\%, 1/89) and subtype C (1.1\%, 1/89). B/F1 and B/C intersubtype recombinants represented 11.2\% (10/89). In Piau√≠ State extensive testing of incidence and transmitted-drug-resistance in all populations with risk behaviors may help control AIDS epidemic locally. ¬© 2015 Wiley Periodicals, Inc. This article was published in J Med Virol and referenced in Journal of AIDS & Clinical Research

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