Author(s): Papasteriades C, Hatziyannakos D, Siakotos M, Pappas H, Tarassi K,
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Abstract Serological HLA-A, B, C, DR and DQ typing was performed in 23 patients with microscopic polyarteritis and renal involvement and in 405 healthy individuals, all of Greek origin. An increased frequency of HLA-A26 (26\% vs. 11.3\%, x2 = 4.423, p < 0.05) and HLA-A11 (26\% vs. 9.6\%, x2 = 6.825, P < 0.02), and a decreased frequency of HLA-DR3 (4.3\% vs. 24.1\%, x2 = 5.935, p < 0.025) were found. Five out of six patients, who did not respond to treatment possessed HLA-DR5. These observations suggest that HLA gene products may influence the clinical expression, as well as the outcome of this disease.
This article was published in Dis Markers
and referenced in Journal of Vasculitis