alexa HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus.
Immunology

Immunology

Journal of Clinical & Cellular Immunology

Author(s): Todd JA, Bell JI, McDevitt HO

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Abstract Over half of the inherited predisposition to insulin-dependent diabetes mellitus maps to the region of chromosome 6 that contains the highly polymorphic HLA class II genes which determine immune responsiveness. Analysis of DNA sequences from diabetics indicates that alleles of HLA-DQ beta determine both disease susceptibility and resistance, and that the structure of the DQ molecule, in particular residue 57 of the beta-chain, specifies the autoimmune response against the insulin-producing islet cells. This article was published in Nature and referenced in Journal of Clinical & Cellular Immunology

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