alexa HLA-DRB1*01 associated with cutaneous hypersensitivity induced by nevirapine and efavirenz.
Pharmaceutical Sciences

Pharmaceutical Sciences

Journal of Pharmacogenomics & Pharmacoproteomics

Author(s): Vitezica ZG, Milpied B, Lonjou C, Borot N, Ledger TN,

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Abstract HLA typing, demographic and immunological risk factors for nevirapine and efavirenz reactions were studied in a French cohort of HIV patients. Cases with isolated rash were significantly associated with HLA-DRB101 allele. No liver toxicity was observed and no association was detected with the percentage of CD4 T-cells. This study suggests that HLA-DRB101 allele plays an important role in susceptibility to cutaneous reactions associated with nevirapine and efavirenz in HIV patients. This article was published in AIDS and referenced in Journal of Pharmacogenomics & Pharmacoproteomics

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