alexa Holographic microrheology of polysaccharides from Streptococcus mutans biofilms


Journal of Oral Hygiene & Health

Author(s): F C Cheong, S Duarte, SH Lee, D G Grier

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We use three-dimensional holographic parti- cle tracking to perform microrheological measurements of model gelled media, including the polysaccharide pel- licle of dental biofilms created by the common cario- genic oral pathogen Streptococcus mutans . Nanometer- resolution video-rate holographic tracking of embed- ded colloidal spheres provides accurate measurements of the gels’ complex viscoelastic moduli, including in- sights into these properties’ heterogeneity. When ap- plied to polysaccharides of S. mutans biofilms, these techniques promise quantitative microscopic assays for candidate therapeutic agents against cariogenic dental biofilms.

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This article was published in Rheologica Acta and referenced in Journal of Oral Hygiene & Health

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