alexa Host immunological mechanisms in the resistance of mice to leptospiral infections.
Immunology

Immunology

Journal of Vaccines & Vaccination

Author(s): Adler B, Faine S

Abstract Share this page

Abstract Several serovars of Leptospira virulent for hamsters and guinea pigs caused acute lethal leptospirosis in mice immunosuppressed with cyclophosphamide. Neither BCG vaccine nor Corynebacterium parvum suspension influenced the course of leptospiral infection in either immunosuppressed or normal BALB/c mice. Nude athymic mice produced anti-leptospiral antibody and were therefore resistant to infection with leptospires. Nude mice were made susceptible with cyclophosphamide but were immune if they had acquired antibody from previous infection or immunization. The evidence suggests that mechanisms of resistance to primary infection and immunity to reinfection are exclusively humorally mediated in mice. The roles of host and microbial factors in the outcome of infection are discussed.
This article was published in Infect Immun and referenced in Journal of Vaccines & Vaccination

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords