alexa Hot-melt extrusion technology: Optimizing drug delivery
Pharmaceutical Sciences

Pharmaceutical Sciences

Journal of Molecular Pharmaceutics & Organic Process Research

Author(s): Gavin P Andrews, David S Jones

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Hot-melt extrusion (HME) technology was first utilised predominantly in the plastic industry and to a lesser extent in the food industry since the 1930s. The many advantages of HME over conventional solid dosage form manufacturing have piqued the interest of the pharmaceutical industry and academia as a novel drug delivery technology. This innovative technology has been shown to be extremely robust and a viable method of producing many different drug delivery systems, including implantable reservoirs, pellets, films, capsules and tablets. Moreover, the possibility of forming solid dispersions offering improved bioavailability renders HME an excellent alternative to other conventionally employed techniques. This article aims to provide, an overview of the technique, a basic guide to extrusion equipment and process technology, the fundamental principles of operation and to discuss themost recent applications of HME within the field of drug delivery

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This article was published in Journal of Molecular Pharmaceutics & Organic Process Research and referenced in Journal of Molecular Pharmaceutics & Organic Process Research

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