Author(s): Toyoshima C
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Abstract Ca2+-ATPase of muscle sarcoplasmic reticulum is an ATP-powered Ca2+-pump that establishes a >10,000 fold concentration gradient across the membrane. Its crystal structures have been determined for 9 different states that cover nearly the entire reaction cycle. Presented here is a brief structural account of the ion pumping process, with emphasis on why the structure has to be so.
This article was published in Biochim Biophys Acta
and referenced in Journal of Genetic Syndromes & Gene Therapy