alexa How interferon-gamma keeps autoimmune diseases in check.


Journal of Clinical & Experimental Ophthalmology

Author(s): Kelchtermans H, Billiau A, Matthys P

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Abstract Interferon-gamma (IFN-gamma) is regarded traditionally as a proinflammatory factor and as the signature cytokine of Th1-dominated autoimmune processes. Early evidence indicative of an opposite, protective role has recently received further attention from reports revealing an increasing number of pathways by which IFN-gamma can counteract harmful inflammation in Th1-associated autoimmune diseases. Here, we review evidence for IFN-gamma's anti-inflammatory effects primarily from the perspective of one experimental model, collagen-induced arthritis (CIA), and question the classic proinflammatory role of IFN-gamma and also the Th1-Th2 paradigm as a basis for explaining the regulation of autoimmune diseases. We conclude that endogenous production of IFN-gamma during inflammatory and autoimmune diseases should be considered as a process with bidirectional immunoregulatory consequences, often resulting in moderation of pathology. This article was published in Trends Immunol and referenced in Journal of Clinical & Experimental Ophthalmology

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