alexa How sensitive to clinical change are ETDRS logMAR visual acuity measurements?
Bioinformatics & Systems Biology

Bioinformatics & Systems Biology

Journal of Computer Science & Systems Biology

Author(s): Rosser DA, Cousens SN, Murdoch IE, Fitzke FW, Laidlaw DA

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Abstract PURPOSE: To determine the sensitivity to change and specificity achieved when published test-retest variability (TRV) data are used to determine whether measured changes in ETDRS logarithm of the minimum angle of resolution (logMAR) visual acuity reflect true clinical change or are attributable to measurement error alone. METHODS: Various degrees of change in visual acuity were simulated in a group of normal subjects by adjusting test difficulty through manipulation of viewing distance. Sensitivity to simulated change and specificity were determined with change criteria derived from published Bland-Altman 95\% ranges for TRV. RESULTS: The relationship between viewing distance and measured acuity was as predicted theoretically. Simulated acuity change of 0.2 logMAR (two lines of letters) or greater can be reliably distinguished from no change (both sensitivity and specificity >95\%) with the ETDRS chart, but a change of 0.1 logMAR or less cannot. CONCLUSIONS: The use of 95\% ranges for TRV to establish the smallest measured visual acuity change that can be reliably detected ensures a high specificity but does not take account of sensitivity. Use of change criteria derived from published 95\% ranges results in a sensitivity of approximately 50\% (assuming identical levels of TRV). Sensitivity may be improved by using a change criterion that is smaller than the minimum change sought, providing the change criterion is still at least as large as the 95\% range for TRV, so that specificity is maintained. Reducing TRV allows smaller changes in acuity to be reliably detected.
This article was published in Invest Ophthalmol Vis Sci and referenced in Journal of Computer Science & Systems Biology

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