alexa How to improve the probability of pregnancy in poor responders undergoing in vitro fertilization: a systematic review and meta-analysis.
Reproductive Medicine

Reproductive Medicine

Reproductive System & Sexual Disorders: Current Research

Author(s): Kyrou D, Kolibianakis EM, Venetis CA, Papanikolaou EG, Bontis J,

Abstract Share this page

Abstract OBJECTIVE: To systematically review the literature to identify randomized controlled trials, which evaluate interventions aiming to improve the probability of pregnancy in poor responders undergoing in vitro fertilization (IVF). DESIGN: Systematic review and meta-analysis. SETTING: University-based hospital. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Pregnancy rate. RESULT(S): Twenty-two eligible randomized controlled trials were identified that evaluated in total 15 interventions to increase pregnancy rates in poor responders. Based on limited evidence, the only interventions that appear to increase the probability of pregnancy were the addition of GH to ovarian stimulation (odds ratio for live birth: 5.22, confidence interval: 95\% 1.09-24.99) and the performance of embryo transfer on day 2 compared with day 3 (ongoing pregnancy rate: 27.7\% vs. 16.3\%, respectively; difference: +11.4, 95\% confidence interval: +1.6 to +21.0). CONCLUSION(S): Insufficient evidence exists to recommend most of the treatments proposed to improve pregnancy rates in poor responders. Currently, there is some evidence to suggest that addition of GH, as well as performing embryo transfer on day 2 versus day 3, appear to improve the probability of pregnancy. This article was published in Fertil Steril and referenced in Reproductive System & Sexual Disorders: Current Research

Relevant Expert PPTs

Recommended Conferences

  • Annual Summit on HIV/AIDS, STDs & STIs
    Aug 07-09, 2017, Beijing, China

  • International Meeting on Women's Health and Breast Cancer
    Oct 12, 2017, Dubai, UAE
  • International Conference on Gynecology and Obstetrics Pathology
    October 23-24, 2017 Orlando, USA
  • 5th International Conference on HIV/AIDS, STDs and STIs
    Nov 13-14, 2017, Las Vegas, Nevada, USA

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords