alexa HSP65 DNA as therapeutic strategy to treat experimental paracoccidioidomycosis.


Journal of Vaccines & Vaccination

Author(s): Ribeiro AM, Bocca AL, Amaral AC, Souza AC, Faccioli LH,

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Abstract The conventional treatment for paracoccidioidomycosis, the most prevalent mycosis in Latin America, involves long periods of therapy resulting in sequels and high frequency of relapses. The search for new alternatives of treatment is necessary. Previously, we have demonstrated that the hsp65 gene from Mycobacterium leprae shows prophylactic effects against murine paracoccidioidomycosis. Here, we tested the DNAhsp65 immunotherapy in BALB/c mice infected with Paracoccidioides brasiliensis, the agent of paracoccidioidomycosis. We observed an increase of Th1 cytokines accompanied by a reduction in fungal burden and pulmonary injury. These results provide new prospects for immunotherapy of paracoccidioidomycosis and other mycoses. Copyright (c) 2009 Elsevier Ltd. All rights reserved. This article was published in Vaccine and referenced in Journal of Vaccines & Vaccination

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