alexa HTLV-1 cosmopolitan and HTLV-2 subtype b among pregnant women of non-endemic areas of Argentina.
Infectious Diseases

Infectious Diseases

Journal of AIDS & Clinical Research

Author(s): Berini CA, Delfino C, Torres O, Garca G, Espejo R, , Berini CA, Delfino C, Torres O, Garca G, Espejo R,

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Abstract OBJECTIVES: The objective of this study was to estimate the prevalence of human T cell lymphotropic virus (HTLV)-1/2, HIV-1, hepatitis B virus (HBV), Trypanosoma cruzi, Treponema pallidum and Toxoplasma gondii infections and to identify the subtypes/subgroups of HTLV-1/2 among pregnant women (PW) from non-endemic provinces of Argentina. METHODS: Methods A total of 2403 samples were screened for HTLV-1/2 and confirmed by western blot and PCR. The long terminal repeat (LTR) of HTLV-1 and HTLV-2 were amplified. Phylogenetic analysis was performed by Neighbour Joining by using molecular evolutionary genetics analysis (MEGA) 4.0. RESULTS: Among a total of 2403 PW studied, 6 (0.25\%) tested positive for HTLV-1/2 (3 HTLV-1 (0.12\%) and 3 HTLV-2 (0.12\%)). The total prevalence when distributed by province was 0.3\% (3/804) for Buenos Aires (BA), 0.4\% (1/241) for BA surroundings, 0.1\% (1/707) for Neuquen and 1.0\% (1/95) for Ushuaia. In San Juan, no PW were HTLV-1/2 positive. The prevalence was similar when compared with rates among blood donors of the same areas and years. The phylogenetic analysis classified one sequence as HTLV-1 aA and one as HTLV-2b. The prevalence of HIV-1, HBV, T cruzi, T pallidum and T gondii was 0.6\%, 0.2\%, 1.4\%, 1.2\% and 20.9\%, respectively. One case of HTLV-1/HIV-1 and one of HTLV-2/HIV-1 co-infection were detected. CONCLUSIONS: HTLV-1/2, which have been associated with different diseases, are circulating among PW of Argentina, even in non-endemic areas. Therefore, testing should be recommended in women who have risk factors for these infections given that the majority of HTLV-1/2 mother to child transmission can be prevented by the avoidance of breast feeding. This article was published in Sex Transm Infect and referenced in Journal of AIDS & Clinical Research

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