alexa Human beta-defensin 1: a restless warrior against allergies, infections and cancer.
Haematology

Haematology

Journal of Blood Disorders & Transfusion

Author(s): PradoMontes de Oca E

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Abstract Human beta-defensin 1 (hBD-1) is probably the most important antimicrobial peptide in epithelial tissues. Its alleles and/or altered gene expression have been associated with at least 20 human diseases. hBD-1 is a tumor suppressor and DEFB1 is the only innate immunity gene that shows long-term balanced selection and heterozygote advantage. It is unique in its constitutive expression, but is still capable of upregulation upon inflammatory or microbial stimuli. The present minireview focuses on hBD-1 properties, biological function, its proposed pathogenic mechanisms and the potential uses of elicitors, inhibitors or the peptide itself in the treatment of hBD-1-related human diseases including allergies, infections and cancer. Copyright 2010 Elsevier Ltd. All rights reserved. This article was published in Int J Biochem Cell Biol and referenced in Journal of Blood Disorders & Transfusion

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