alexa Human heart glutamate receptors - implications for toxicology, food safety, and drug discovery.
Psychiatry

Psychiatry

Journal of Addiction Research & Therapy

Author(s): Gill S, Veinot J, Kavanagh M, Pulido O

Abstract Share this page

Abstract Excitatory amino acids (EAAs) mediate their effects through the glutamate receptors (GluRs) in the brain. GluRs play an important role in the treatment of a variety of neuropsychiatric conditions and are central to the neurotoxicity of EAAs such as domoic and kainic acid. Unstained histological preparations of human heart tissues were used for the histopathological assessment, the anatomical identification of specific cardiac structures and the presence of the GluRs. Immunohistochemical stains with the biomarkers protein gene product (PGP 9.5) and the neurofilaments (NF 160 and NF 200) were used to identify neural structures and the components of the conducting system. Several subtypes of GluRs were differentially expressed and each had a specific distribution. In contrast to nonhuman primates, GluRs are more widely expressed in humans, where the working myocardium and the wall of blood vessels stained for GluRs. The immunolabelling was observed within the specialized structures of the conducting system, intramural nerves, and ganglia cells. These receptors may be involved in important cardiac functions such as contraction, rhythm, coronary circulation, and thus may be implicated in the pathobiology of some cardiac disease. The GluRs in the heart could be targets for the effects of excitatory compounds and is therefore an important consideration for the safety evaluation of foods and therapeutic products. This article was published in Toxicol Pathol and referenced in Journal of Addiction Research & Therapy

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords