Author(s): Rota S, Beyazova U, Karsligil T, Cevherolu C
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Abstract An ELISA assay based on the A-60 antigen complex from Mycobacterium bovis BCG cytoplasm was used to detect anti-mycobacterial antibodies of different classes in the sera of 63 BCG-vaccinated infants during the 6-month post-vaccination period. The mean IgM and IgA levels increased, whereas the mean IgG level decreased after BCG vaccination. However, in a minority of cases only Ig levels were above the cut-off line: this was true for IgM in 11/63 (17\%) cases and for IgA in 14/63 (22\%) of cases but none of the tested infants was anti-A60 IgG ELISA positive. Fifty-two infants (83\%) were tuberculin-positive eight weeks after vaccination, and no significant difference in mean antibody levels of tuberculin-positive and negative cases was observed, except for IgG (p < 0.05).
This article was published in Eur J Epidemiol
and referenced in Clinical Microbiology: Open Access