alexa Hyaluronan- and heparin-reduced silver nanoparticles with antimicrobial properties.
Materials Science

Materials Science

Journal of Nanomedicine & Biotherapeutic Discovery

Author(s): Kemp MM, Kumar A, Clement D, Ajayan P, Mousa S,

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Abstract AIMS: Silver nanoparticles exhibit unique antibacterial properties that make these ideal candidates for biological and medical applications. We utilized a clean method involving a single synthetic step to prepare silver nanoparticles that exhibit antimicrobial activity. MATERIALS & METHODS: These nanoparticles were prepared by reducing silver nitrate with diaminopyridinylated heparin (DAPHP) and hyaluronan (HA) polysaccharides and tested for their efficacy in inhibiting microbial growth. RESULTS & DISCUSSION: The resulting silver nanoparticles exhibit potent antimicrobial activity against Staphylococcus aureus and modest activity against Escherichia coli. Silver-HA showed greater antimicrobial activity than silver-DAPHP, while silver-glucose nanoparticles exhibited very weak antimicrobial activity. Neither HA nor DAPHP showed activity against S. aureus or E. coli. CONCLUSION: These results suggest that DAPHP and HA silver nanoparticles have potential in antimicrobial therapeutic applications.
This article was published in Nanomedicine (Lond) and referenced in Journal of Nanomedicine & Biotherapeutic Discovery

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