alexa Hybrid liposomes affect cellular lipid constituents and caveolae structures.
Oncology

Oncology

Journal of Carcinogenesis & Mutagenesis

Author(s): Cao K, Tanaka K, Komizu Y, TamiyaKoizumi K, Murate T,

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Abstract We examined alterations of lipid constituents induced by hybrid liposomes (HLs) in cancer cells. As early as 1h after HL treatment, amounts of the raft/caveolae lipids sphingomyelin, ceramide, and ether-type PC were altered. In addition, the structures of caveolae on the cytoplasmic surface of the cell membrane were significantly changed. Our results suggest that alterations of lipid composition in caveolae mediate HL signaling for apoptosis. Copyright © 2011 Elsevier Ltd. All rights reserved. This article was published in Bioorg Med Chem Lett and referenced in Journal of Carcinogenesis & Mutagenesis

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