alexa Hydrogen sulfide-induced hypometabolism prevents renal ischemia reperfusion injury.


Journal of Transplantation Technologies & Research

Author(s): Bos EM, Leuvenink HG, Snijder PM, Kloosterhuis NJ, Hillebrands JL,

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Abstract Hydrogen sulfide (H(2)S) can induce a hypometabolic, hibernation-like state in mammals when given in subtoxic concentrations. Pharmacologically reducing the demand for oxygen is a promising strategy to minimize unavoidable hypoxia-induced injury such as ischemia/reperfusion injury during renal transplantation. Here we show that H(2)S reduces metabolism in vivo, ex vivo, and in vitro. Furthermore, we demonstrate the beneficial effects of H(2)S-induced hypometabolism in a model of bilateral renal ischemia/reperfusion injury using three different treatment strategies. The results demonstrate striking protective effects on survival, renal function, apoptosis, and inflammation. A hypometabolic state induced by H(2)S might have therapeutic potential to protect kidneys that suffer from hypoxia.
This article was published in J Am Soc Nephrol and referenced in Journal of Transplantation Technologies & Research

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