Author(s): Maeda H, Okabayashi T, Nishimori I, Yamashita K, Sugimoto T,
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Abstract BACKGROUND AND AIMS: This study assessed glucose metabolism via continuous intraoperative monitoring of blood glucose in patients undergoing hepatic resection. METHODS: Thirty patients who underwent hepatic resection were enrolled. During hepatic resection, blood glucose concentration was continuously measured by an artificial pancreas. RESULTS: Glucose concentrations followed a similar up-and-down pattern in all patients during the Pringle maneuver series. The concentration decreased marginally during the first clamping of the hepatoduodenal ligament but showed a rapid increase after unclamping. However, this increase declined with the number of Pringle cycles (P < .01). Patients with liver cirrhosis showed smaller elevations in glucose concentration after the first unclamping compared with patients without liver cirrhosis (P < .05). CONCLUSIONS: The present study showed a rapid and profound transition in glucose concentration during hepatic resection. The mechanism underlying the transition of blood glucose concentration may involve glycogen break down within hepatocytes because of hypoxia.
This article was published in Am J Surg
and referenced in Journal of Anesthesia & Clinical Research