alexa Hypertrophy of the heart: a new therapeutic target?
Clinical Research

Clinical Research

Journal of Clinical Case Reports

Author(s): Frey N, Katus HA, Olson EN, Hill JA

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Abstract Recent studies call into question the necessity of hypertrophic growth of the heart as a "compensatory" response to hemodynamic stress. These findings, coupled with recent progress in dissecting the molecular bases of hypertrophy, raise the prospect of suppressing hypertrophy without provoking circulatory insufficiency. In this article, we focus on signaling pathways that hold promise as potential targets for therapeutic intervention. We also summarize observations from animal models and clinical trials that suggest benefit from an antihypertrophic strategy. This article was published in Circulation and referenced in Journal of Clinical Case Reports

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