Author(s): Dasgupta A, Sarma D, Saikia UK
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Abstract INTRODUCTION: Hypomagnesemia is reported in type 2 diabetes; magnesium deficiency may play a role in the development of endothelial dysfunction and altered insulin function. OBJECTIVE: To assess the incidence of hypomagnesemia among noncritically ill patients of Type 2 diabetes mellitus and to evaluate the relation of hypomagnesemia to glycemic control and various long-term complications of diabetes mellitus. MATERIALS AND METHODS: One hundred and fifty, noncritically ill (APACHE score < 10) type 2 diabetes mellitus patients, who were admitted in the Departments of Medicine and Endocrinology, GMCH for uncontrolled hyperglycemia and/or various diabetic complications were studied. Serum magnesium was assessed at admission and rechecked in those found to be deficient. RESULTS: Hypomagnesemia (Se magnesium < 1.6 mg/dl) was documented in 17 (11.33\%) patients with a female:male ratio of 9:8. Mean HbA1c was 11.9\% in the hypomagnesemic patients compared with 9.8\% in controls (P =0.0016). Retinopathy, microalbuminuria, macroalbuminuria, foot ulceration, and neuropathy was present in 64\%, 47\%, 17.64\%, 58.8\%, and 82.35\%, respectively, of the patients with hypomagnesemia as compared with 45.8\% (P =0.118), 38.34\% (P =0.704),15.03\% (P =0.566), 22.55\% (P =0.011) and 82.7\% (P =0.976) without hypomagnesemia. Coronary artery disease was less common in the hypomagnesemia group (17.6\% vs 39\%), but comparable in the subgroup < 50 years (27\% vs 25\%) (P =0.796). CONCLUSION: Hypomagnesemia in diabetes was associated with poorer glycemic control, retinopathy, nephropathy, and foot ulcers.
This article was published in Indian J Endocrinol Metab
and referenced in Journal of Diabetes & Metabolism