alexa Hypophosphatasia affecting the permanent dentition.
Molecular Biology

Molecular Biology

Journal of Cytology & Histology

Author(s): Olsson A, Matsson L, Blomquist HK, Larsson A, Sjdin B

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Abstract Reports on dental abnormalities in connection with hypophosphatasia almost exclusively describe changes in primary teeth. A 23-year-old man with hypophosphatasia, first diagnosed at the age of 8 months, is described; histologically and radiographically verified signs of the condition were present in the permanent dentition. The findings included a reduced level of the marginal alveolar bone supporting the upper central incisors, which had to be extracted. The molars displayed large coronal pulp chambers. Histologically, the upper incisors demonstrated abnormal root cementum, with areas of dentin resorption, as well as disturbances of the mineralization of the coronal dentin. The patient also had signs of abnormal root resorption of molars. The potential involvement of permanent teeth puts children with hypophosphatasia at risk of developing oral complications during adolescent and adult life.
This article was published in J Oral Pathol Med and referenced in Journal of Cytology & Histology

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