Author(s): Kamata K, Noguchi M, Nagai M
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Abstract 1. The in vivo and in vitro effects of lithospermic acid B (LSA-B), which was extracted from Salviae miltiorrhizae Radix, on vascular relaxation responses were examined in rats. 2. Intravenous injection of LSA-B (10-30 mg/kg) decreased the blood pressure in a dose-dependent manner. 3. In perfused mesenteric arterial bed precontracted with methoxamine (10(-5) M), LSA-B (10(-5) - 10(-3) M) produced a concentration-dependent relaxation. 4. Vasodilator response of the mesentery in response to LSA-B was reversed by 10(-4) M NG-monomethyl-L-arginine (L-NMMA). 5. The inhibition of vasodilation by L-NMMA was reversed by L-arginine (3 x 10(-4) M). 6. These results suggest that LSA-B-induced hypotensive effect may be due to the endothelium-dependent vasodilation of resistance artery such as mesenteric arterial bed.
This article was published in Gen Pharmacol
and referenced in Medicinal Chemistry