alexa Hypoxia induces up-regulation of progranulin in neuroblastoma cell lines.
Molecular Biology

Molecular Biology

Journal of Cytology & Histology

Author(s): Piscopo P, Rivabene R, Adduci A, Mallozzi C, MalvezziCampeggi L,

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Abstract Progranulin (PGRN) is a widely expressed multifunctional protein, involved in regulation of cell growth and cell cycle progression with a possible involvement in neurodegeneration. We looked for PGRN regulation in three different human neuroblastoma cell lines, following exposure to two different stimuli commonly associated to neurodegeneration: hypoxia and oxidative stress. For gene and protein expression analysis we carried out a quantitative RT-PCR and western blotting analysis. We show that PGRN is strongly up-regulated by hypoxia, through the mitogen-actived protein kinase (MAPK)/extracellular signal-regulated kinase (MEK) signaling cascade. PGRN is not up-regulated by H(2)O(2)-induced oxidative stress. These results suggest that PGRN in the brain could exert a protective role against hypoxic stress, one of principal risk factors involved in frontotemporal dementia pathogenesis. Copyright © 2010 Elsevier Ltd. All rights reserved. This article was published in Neurochem Int and referenced in Journal of Cytology & Histology

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