alexa Iatrogenic iodine as a cause of hypothyroidism in infants with end-stage renal failure.
Diabetes & Endocrinology

Diabetes & Endocrinology

Journal of Thyroid Disorders & Therapy

Author(s): Brough R, Jones C

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Abstract Between 1996 and 2005, two of seven infants in our unit on overnight continuous-cycle peritoneal dialysis (CCPD) acquired hypothyroidism following normal thyroid function on neonatal screening. Case 1 had posterior urethral valves, commenced CCPD at day 29, and developed hypothyroidism requiring treatment at 3 months: TSH 258 micro/l (ref.: 0.3-3.8), total thyroxine 74 nmol/l (ref.: 77-159). Plasma iodine concentration was 7.44 micromol/l (ref.: 0.23-0.68). Iodine concentrations in peritoneal dialysis (PD) fluid were found to be higher at the end of the first cycle (11.4 micromol/l) than at the end of the twelfth cycle (1.55 micromol/l). Case 2 had posterior urethral valves, commenced CCPD on day 4 and was diagnosed with hypothyroidism following a prolonged jaundice screen. Thyroxine replacement was stopped 2 months after a renal transplant. A third child commenced CCPD on day 2 and had high plasma iodine concentrations at 8 weeks (5.79 micromol/l). He had borderline thyroid function, not requiring replacement. Our hypothesis is that these infants developed hypothyroidism as a consequence of iodine exposure via the Wolff-Chaikoff effect. Iodine levels were higher in the PD fluid than in plasma. This suggests that povidine-iodine 10\% in the PD cap may be the source of the high plasma iodine levels. This article was published in Pediatr Nephrol and referenced in Journal of Thyroid Disorders & Therapy

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