alexa Identification and inhibition of the ICE CED-3 protease necessary for mammalian apoptosis.
Reproductive Medicine

Reproductive Medicine

Andrology-Open Access

Author(s): Nicholson DW, Ali A, Thornberry NA, Vaillancourt JP, Ding CK,

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Abstract The protease responsible for the cleavage of poly(ADP-ribose) polymerase and necessary for apoptosis has been purified and characterized. This enzyme, named apopain, is composed of two subunits of relative molecular mass (M(r)) 17K and 12K that are derived from a common proenzyme identified as CPP32. This proenzyme is related to interleukin-1 beta-converting enzyme (ICE) and CED-3, the product of a gene required for programmed cell death in Caenorhabditis elegans. A potent peptide aldehyde inhibitor has been developed and shown to prevent apoptotic events in vitro, suggesting that apopain/CPP32 is important for the initiation of apoptotic cell death. This article was published in Nature and referenced in Andrology-Open Access

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