alexa Identification and quantitative determination of fentanyl metabolites in patients by gas chromatography--mass spectrometry.
General Science

General Science

Journal of Forensic Research

Author(s): Goromaru T, Matsuura H, Yoshimura N, Miyawaki T, Sameshima T, , Goromaru T, Matsuura H, Yoshimura N, Miyawaki T, Sameshima T,

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Abstract Although fentanyl has been used widely as a short-acting narcotic analgesic, its metabolism in humans has not been clarified. In this study, three fentanyl metabolites were identified in the urine of eight surgical patients receiving 0.3-0.5 mg of fentanyl intravenously. The metabolites 4-N-(N-propionylanilino)piperidine, 4-N-(N-hydroxypropionylanilino)piperidine and 1-(2-phenethyl)-4-N-(N-hydroxypropionylanilino)piperidine, and unchanged fentanyl were identified by GC-mass spectrometry in urine collected 6 h after administration. Fentanyl and its main metabolite, 4-N-(N-propionylanilino)piperidine, were determined quantitatively in the urine of five additional patients receiving 0.5 mg fentanyl intravenously. Urinary excretion of fentanyl and 4-N-(N-propionylanilino)-piperidine during the first 12 h after injection accounted for 0.3-4.0\% and 26 to 55\% of the dose, respectively.
This article was published in Anesthesiology and referenced in Journal of Forensic Research

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