Author(s): Koch P, Bohlmann I, Schfer M, HansenHagge TE, Kiyoi H, , Koch P, Bohlmann I, Schfer M, HansenHagge TE, Kiyoi H,
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Abstract In the process of cloning genes at the breakpoint of t(5;14) (q34;q11), a recurring translocation in acute lymphoblastic leukemia, we isolated and characterized a novel gene at 5q34, and a close human homologue (66\% amino acid identity) located at 8p11-12. The presence of an importin-beta N-terminal domain at their N-terminus, their size of approximately 110 kD, their nuclear localization and the identity of the homologue to a gene of a recently submitted RanGTP binding protein (RanBP16), suggest that its protein is a novel member of the importin-beta superfamily of nuclear transport receptors, therefore called RanBP17. Northern blot analysis of human tissues revealed a ubiquitous expression pattern of the RanBP16 gene and a very restricted expression pattern of the RanBP17 gene, showing high expression in testis and pancreas. Both genes are evolutionary conserved and show a high (99 and 94\%) amino acid conservation with their murine counterparts and a striking similarity (40\%) to a protein product of Caenorhabditis elegans (C35A5.8). Copyright 2000 Academic Press.
This article was published in Biochem Biophys Res Commun
and referenced in Journal of Clinical & Experimental Pharmacology