alexa Identification of arylsulfonamides as Aquaporin 4 inhibitors.
General Science

General Science

Entomology, Ornithology & Herpetology: Current Research

Author(s): Huber VJ, Tsujita M, Yamazaki M, Sakimura K, Nakada T

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Abstract Carbonic anhydrase inhibitors AZA, EZA, and 4-acetamidobenzsulfonamide were found to inhibit human AQP4-M23 mediated water transport by 80\%, 68\%, and 23\%, respectively, at 20 microM in an in vitro functional assay. AZA was found to have an IC50 against AQP4 of 0.9 microM. Phloretin was inactive under the same conditions. This article was published in Bioorg Med Chem Lett and referenced in Entomology, Ornithology & Herpetology: Current Research

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