alexa Identification of some lectin IB4 binding proteins in rat dorsal root ganglia.


Journal of Clinical & Experimental Dermatology Research

Author(s): Fullmer JM, Riedl MS, Higgins L, Elde R, Fullmer JM, Riedl MS, Higgins L, Elde R

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Abstract Lectins are proteins that bind to glycoproteins and glycolipids. The isolectin Griffonia simplicifolia I-B4 (IB4) recognizes terminal alpha-galactose and binds to a subset of small and medium-sized neurons in the dorsal root ganglia (DRG). Using one and two-dimensional gel electrophoresis, we have identified several proteins that bind IB4 in sciatic nerve, dorsal horn, and DRG. Treatment with the enzyme alpha-galactosidase reduces IB4 binding, strongly suggesting the binding is specific for the IB4 epitope. Mass spectrometric analysis of tryptic digests of alpha-galactosidase sensitive bands identified three proteins that bind IB4: the laminin beta 2 chain and the light and medium subunits of neurofilaments.
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This article was published in Neuroreport and referenced in Journal of Clinical & Experimental Dermatology Research

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