alexa Identification of the bleomycin hydrolase gene as a methylated tumor suppressor gene in hepatocellular carcinoma using a novel triple-combination array method
Oncology

Oncology

Journal of Carcinogenesis & Mutagenesis

Author(s): Okamura Y, Nomoto S, Hayashi M, Hishida M, Nishikawa Y

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In the present study, we sought to identify novel suppressor genes of hepatocellular carcinoma (HCC) using our newly designed triple-combination array. Using this method, the bleomycin hydrolase gene (BLMH) was detected as a candidate suppressor gene. We found that 28 of 48 (58.3%) tumor tissues showed BLMH promoter hypermethylation, and its expression level was significantly reduced in tumor tissues (P=0.001). The present study suggests that our new method can detect novel genes of interest and that BLMH is a suppressor gene in HCC.

This article was published in Cancer Lett. and referenced in Journal of Carcinogenesis & Mutagenesis

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