Author(s): Colom F
To review the definition of non-adherence, its clinical and economic impact and identify its role and impact in clinical practice. METHODS: A selective review of the literature as conducted of articles and literature known to the authors. RESULTS: There is a paucity of studies examining specifically treatment non-adherence and its consequences in bipolar disorder. Few studies have systematically examined ways in which treatment adherence can impact treatment and improve outcome. CONCLUSION: Non-adherence is common in the management of bipolar disorder. Clinicians and Researchers alike need to remain alert and be aware of issues related to non-adherence--in particular suicide. Like other course-modifiers non-adherence has to be considered, sought and addressed, and this is perhaps best done by including psychoeducation in routine clinical care.