alexa IL-17 receptor signaling and T helper 17-mediated autoimmune demyelinating disease.


Journal of Clinical & Cellular Immunology

Author(s): Zepp J, Wu L, Li X

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Abstract Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS). Experimental autoimmune encephalomyelitis (EAE) is widely used to dissect molecular mechanisms of MS and to develop new therapeutic strategies. The T helper 17 (Th17) subset of CD4 T cells plays a crucial role in the development of EAE. IL-17, a cytokine produced by Th17 cells, participates in EAE pathogenesis through induction of inflammatory gene expression in target cells. Recent work has shown that Act1, a U-box E3 ubiquitin ligase, is recruited to IL-17 receptor (IL-17R) upon IL-17 stimulation and is required for IL-17-mediated signaling. Here, we review the molecular and cellular mechanisms by which IL-17 and Act1-mediated signaling contribute to EAE. Copyright © 2011 Elsevier Ltd. All rights reserved.
This article was published in Trends Immunol and referenced in Journal of Clinical & Cellular Immunology

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