alexa Imaging proliferation in vivo with [F-18]FLT and positron emission tomography.
Immunology

Immunology

Immunotherapy: Open Access

Author(s): Shields AF, Grierson JR, Dohmen BM, Machulla HJ, Stayanoff JC, , Shields AF, Grierson JR, Dohmen BM, Machulla HJ, Stayanoff JC, , Shields AF, Grierson JR, Dohmen BM, Machulla HJ, Stayanoff JC, , Shields AF, Grierson JR, Dohmen BM, Machulla HJ, Stayanoff JC,

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Abstract Positron emission tomography (PET) is now regularly used in the diagnosis and staging of cancer. These uses and its ability to monitor treatment response would be aided by the development of imaging agents that can be used to measure tissue and tumor proliferation. We have developed and tested [F-18]FLT (3'-deoxy-3'-fluorothymidine); it is resistant to degradation, is retained in proliferating tissues by the action of thymidine kinase 1 (TK), and produces high-contrast images of normal marrow and tumors in canine and human subjects. This article was published in Nat Med and referenced in Immunotherapy: Open Access

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