alexa Immune attack: the role of inflammation in Alzheimer disease.
Neurology

Neurology

Journal of Alzheimers Disease & Parkinsonism

Author(s): Heppner FL, Ransohoff RM, Becher B, Heppner FL, Ransohoff RM, Becher B

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Abstract The past two decades of research into the pathogenesis of Alzheimer disease (AD) have been driven largely by the amyloid hypothesis; the neuroinflammation that is associated with AD has been assumed to be merely a response to pathophysiological events. However, new data from preclinical and clinical studies have established that immune system-mediated actions in fact contribute to and drive AD pathogenesis. These insights have suggested both novel and well-defined potential therapeutic targets for AD, including microglia and several cytokines. In addition, as inflammation in AD primarily concerns the innate immune system - unlike in 'typical' neuroinflammatory diseases such as multiple sclerosis and encephalitides - the concept of neuroinflammation in AD may need refinement. This article was published in Nat Rev Neurosci and referenced in Journal of Alzheimers Disease & Parkinsonism

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