alexa Immune interferon: a pleiotropic lymphokine with multiple effects.


Journal of Vaccines & Vaccination

Author(s): Trinchieri G, Perussia B

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Abstract Immune (gamma) interferon (IFN-γ) is produced during an immune response by antigen-specific T cells and probably also by natural killer (NK) cells recruited by the T cell-product interleukin 2 (IL-2). IFN-γ was discovered and originally measured on the basis of its anti-viral activity, but its complex anti-cellular activities probably reflect its biological role more clearly. In this review, Giorgio Trinchieri and Bice Perussia discuss some aspects of the biology of IFN-γ, its pleiomorphic anti-cellular effects and its ability to modulate cellular responses to other regulatory factors. Copyright © 1985. Published by Elsevier B.V. This article was published in Immunol Today and referenced in Journal of Vaccines & Vaccination

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